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1

The oncolytic adenovirus VCN-01 promotes anti-tumor effect in primitive neuroectodermal tumor models

Garcia-Moure, Marc, Martinez-Velez, Naiara, Gonzalez-Huarriz, Marisol, Marrodán, Lucía, Cascallo, Manel, Alemany, Ramón, Patiño-García, Ana, Alonso, Marta M.

Journal:

Scientific Reports

Year:

2019

File:

PDF, 1.63 MB

2019

2

Genetic background determines the response to adenovirus-mediated wild-type p53 expression in pancreatic tumor cells

Cascalló, M, Mercadé, E, Capellà, G, Lluís, F, Fillat, C, Gómez-Foix, A M, Mazo, A

Journal:

Cancer Gene Therapy

Year:

1999

Language:

english

File:

PDF, 2.92 MB

english, 1999

3

Safety and Efficacy of VCN-01, an Oncolytic Adenovirus Combining Fiber HSG-Binding Domain Replacement with RGD and Hyaluronidase Expression

Rodriguez-Garcia, A., Gimenez-Alejandre, M., Rojas, J. J., Moreno, R., Bazan-Peregrino, M., Cascallo, M., Alemany, R.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 987 KB

english, 2015

4

Positive selection of gene-modified cells increases the efficacy of pancreatic cancer suicide gene therapy

Martinez-Quintanilla, J., Cascallo, M., Gros, A., Fillat, C., Alemany, R.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 596 KB

english, 2009

5

Minimal RB-responsive E1A Promoter Modification to Attain Potency, Selectivity, and Transgene-arming Capacity in Oncolytic Adenoviruses

Rojas, Juan J, Guedan, Sonia, Searle, Peter F, Martinez-Quintanilla, Jordi, Gil-Hoyos, Raúl, Alcayaga-Miranda, Francisca, Cascallo, Manel, Alemany, Ramon

Journal:

Molecular Therapy

Year:

2010

Language:

english

File:

PDF, 540 KB

english, 2010

6

Verapamil Enhances the Antitumoral Efficacy of Oncolytic Adenoviruses

Gros, Alena, Puig, Cristina, Guedan, Sonia, Rojas, Juan José, Alemany, Ramon, Cascallo, Manel

Journal:

Molecular Therapy

Year:

2010

Language:

english

File:

PDF, 523 KB

english, 2010

7

Editorial

Rodriguez-Garcia, A., Gimenez-Alejandre, M., Rojas, J., Moreno, R., Bazan-Peregino, M., Cascallo, M., Alemany, R.

Journal:

Companion Animal

Year:

2012

Language:

english

File:

PDF, 267 KB

english, 2012

8

Photo-oxygenation of Styrenic Estrogens: Product characterization and kinetics of the dye-sensitized photo-oxygenation of 9,11-didehydroestrone derivatives

Antoni Planas, Pilar Lupon, Montse Cascallo, Juan-Julio Bonet

Journal:

Helvetica Chimica Acta

Year:

1989

Language:

english

File:

PDF, 514 KB

english, 1989

9

Modulation of drug cytotoxicity by reintroduction of wild-type p53 gene (Ad5CMV-p53) in human pancreatic cancer

Cascalló, Manel, Calbó, Joaquim, Gelpí, Josef Lluís, Mazo, Adela

Journal:

Cancer Gene Therapy

Year:

2000

Language:

english

File:

PDF, 840 KB

english, 2000

10

Adenovirus i-Leader Truncation Bioselected Against Cancer-associated Fibroblasts to Overcome Tumor Stromal Barriers

Puig-Saus, Cristina, Gros, Alena, Alemany, Ramon, Cascalló, Manel

Journal:

Molecular Therapy

Year:

2011

Language:

english

File:

PDF, 446 KB

english, 2011

11

ChemInform Abstract: Photochemical Reactions. Part 23. Photooxygenation of Styrenic Estrogens: Product Characterization and Kinetics of the Dye-Sensitized Photooxygenation of 9,11-Didehydroestrone Derivatives.

PLANAS, A., LUPON, P., CASCALLO, M., BONET, J.-J.

Journal:

Year:

1989

File:

PDF, 132 KB

1989

12

First-in-human dose-escalation study of VCN-01, a selective oncolytic adenovirus with hyaluronidase activity in patients with advanced or metastatic cancer

Hidalgo, M., Gil, M., Garcia-Carbonero, R., Alvarez, R., Laquente, B., Moreno, R., De Martino, A., Alemany, R., Capella, G., Blasi, E., Viaplana, I., Cascallo, M., Salazar, R.

Journal:

European Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 60 KB

english, 2016

13

GALV expression enhances the therapeutic efficacy of an oncolytic adenovirus by inducing cell fusion and enhancing virus distribution

Guedan, S, Grases, D, Rojas, J J, Gros, A, Vilardell, F, Vile, R, Mercade, E, Cascallo, M, Alemany, R

Journal:

Year:

2012

Language:

english

File:

PDF, 669 KB

english, 2012

14

A phase I trial of oncolytic adenovirus ICOVIR-5 administered intravenously to melanoma patients

Garcia, Margarita, Moreno, Rafael, Gil, Marta, Cascallo, Manel, de Olza, Maria Ochoa, Cuadra, Carmen, Piulat, Josep Maria, Navarro, Valentin, Domenech, Marta, Alemany, Ramon, Salazar, Ramon

Journal:

Human Gene Therapy Clinical Development

Year:

2018

Language:

english

File:

PDF, 671 KB

english, 2018

15

Bioselection of a Gain of Function Mutation that Enhances Adenovirus 5 Release and Improves Its Antitumoral Potency

Gros, A., Martinez-Quintanilla, J., Puig, C., Guedan, S., Mollevi, D. G., Alemany, R., Cascallo, M.

Journal:

Cancer Research

Year:

2008

Language:

english

File:

PDF, 647 KB

english, 2008

16

The oncolytic adenovirus VCN-01 as therapeutic approach against pediatric osteosarcoma

Martinez-Velez, N., Xipell, E., Vera, B., acanda de la rocha, A., Zalacain, M., Marrodan, L., Gonzalez-Huarriz, M., Toledo, G., Cascallo, M., Alemany, R., Patino-Garcia, A., Alonso, M. M.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015

17

A phase I trial of oncolytic adenovirus ICOVIR-5 administered intravenously to cutaneous and uveal melanoma patients

Garcia, Margarita, Moreno, Rafael, Gil, Marta, Cascallo, Manel, de Olza, Maria Ochoa, Cuadra, Carmen, Piulat, Josep Maria, Navarro, Valentin, Domenech, Marta, Alemany, Ramon, Salazar, Ramon

Journal:

Human Gene Therapy

Year:

2018

Language:

english

File:

PDF, 440 KB

english, 2018

18

Systemic Toxicity–Efficacy Profile of ICOVIR-5, a Potent and Selective Oncolytic Adenovirus Based on the pRB Pathway

Cascallo, Manel, Alonso, Marta M, Rojas, Juan J, Perez-Gimenez, Anna, Fueyo, Juan, Alemany, Ramon

Journal:

Molecular Therapy

Year:

2007

Language:

english

File:

PDF, 411 KB

english, 2007

19

Vero Cells as a Model to Study the Effects of Adenoviral Gene Delivery Vectors on the RNAi System in Context of Viral Infection

Matskevich, Alexey A., Jung, Jiun-Shan, Sch&uuml, mann, Michael, Cascallo, Manel, Moelling, Karin

Journal:

Journal of Innate Immunity

Year:

2009

Language:

english

File:

PDF, 206 KB

english, 2009

20

The oncolytic adenovirus VCN-01 promotes anti-tumor effect in primitive neuroectodermal tumor models

Garcia-Moure, Marc, Martinez-Velez, Naiara, Gonzalez-Huarriz, Marisol, Marrodán, Lucía, Cascallo, Manel, Alemany, Ramón, Patiño-García, Ana, Alonso, Marta M.

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 1.63 MB

english, 2019

21

Syncytia formation affects the yield and cytotoxicity of an adenovirus expressing a fusogenic glycoprotein at a late stage of replication

Guedan, S, Gros, A, Cascallo, M, Vile, R, Mercade, E, Alemany, R

Journal:

Year:

2008

Language:

english

File:

PDF, 216 KB

english, 2008

22

Control of E1A under an E2F-1 promoter insulated with the myotonic dystrophy locus insulator reduces the toxicity of oncolytic adenovirus Ad-Δ24RGD

Majem, M, Cascallo, M, Bayo-Puxan, N, Mesia, R, Germa, J R, Alemany, R

Journal:

Cancer Gene Therapy

Year:

2006

Language:

english

File:

PDF, 300 KB

english, 2006

23

ICOVIR-5 Shows E2F1 Addiction and Potent Antiglioma Effect In vivo

Alonso, M. M., Cascallo, M., Gomez-Manzano, C., Jiang, H., Bekele, B. N., Perez-Gimenez, A., Lang, F. F., Piao, Y., Alemany, R., Fueyo, J.

Journal:

Cancer Research

Year:

2007

Language:

english

File:

PDF, 757 KB

english, 2007

24

A pRb-responsive, RGD-modified, and Hyaluronidase-armed Canine Oncolytic Adenovirus for Application in Veterinary Oncology

Laborda, Eduardo, Puig-Saus, Cristina, Rodriguez-García, Alba, Moreno, Rafael, Cascalló, Manel, Pastor, Josep, Alemany, Ramon

Journal:

Molecular Therapy

Year:

2014

Language:

english

File:

PDF, 1022 KB

english, 2014

25

Oncolytic Adenovirus ICOVIR-7 in Patients with Advanced and Refractory Solid Tumors

Nokisalmi, P., Pesonen, S., Escutenaire, S., Sarkioja, M., Raki, M., Cerullo, V., Laasonen, L., Alemany, R., Rojas, J., Cascallo, M., Guse, K., Rajecki, M., Kangasniemi, L., Haavisto, E., Karioja-Kall

Journal:

Clinical Cancer Research

Year:

2010

Language:

english

File:

PDF, 287 KB

english, 2010

26

Replacement of Adenovirus Type 5 Fiber Shaft Heparan Sulfate Proteoglycan-Binding Domain with RGD for Improved Tumor Infectivity and Targeting

Bayo-Puxan, Neus, Gimenez-Alejandre, Marta, Lavilla-Alonso, Sergio, Gros, Alena, Cascallo, Manel, Hemminki, Akseli, Alemany, Ramon

Journal:

Human Gene Therapy

Year:

2009

Language:

english

File:

PDF, 38.53 MB

english, 2009

27

Treatment based on a combination of the CYP2B1/cyclophosphamide system and p53 delivery enhances tumour regression in human pancreatic cancer

Mercadé, E., Cascalló, M., Carrió, M., Calbó, J., Gómez-Treviño, A., Fillat, C., Gómez-Foix, A. M., Mazo, A.

Journal:

Annals of Oncology

Year:

2001

Language:

english

File:

PDF, 5.92 MB

english, 2001

28

The combination of i-leader truncation and gemcitabine improves oncolytic adenovirus efficacy in an immunocompetent model

Puig-Saus, C, Laborda, E, Rodríguez-García, A, Cascalló, M, Moreno, R, Alemany, R

Journal:

Cancer Gene Therapy

Year:

2014

Language:

english

File:

PDF, 471 KB

english, 2014

29

Adenovirus-mediated wt-p16 reintroduction induces cell cycle arrest or apoptosis in pancreatic cancer

Calbó, Joaquim, Marotta, Mario, Cascalló, Manel, Roig, Josep Maria, Gelpí, Josep Lluis, Fueyo, Juan, Mazo, Adela

Journal:

Cancer Gene Therapy

Year:

2001

Language:

english

File:

PDF, 485 KB

english, 2001

30

Osteosarcoma cells as carriers to allow antitumor activity of canine oncolytic adenovirus in the presence of neutralizing antibodies

Alcayaga-Miranda, F, Cascallo, M, Rojas, J J, Pastor, J, Alemany, R

Journal:

Cancer Gene Therapy

Year:

2010

Language:

english

File:

PDF, 734 KB

english, 2010

31

Hyaluronidase Expression by an Oncolytic Adenovirus Enhances Its Intratumoral Spread and Suppresses Tumor Growth

Guedan, Sonia, Rojas, Juan José, Gros, Alena, Mercade, Elena, Cascallo, Manel, Alemany, Ramon

Journal:

Molecular Therapy

Year:

2010

Language:

english

File:

PDF, 546 KB

english, 2010

32

A modified E2F-1 promoter improves the efficacy to toxicity ratio of oncolytic adenoviruses

Rojas, J J, Cascallo, M, Guedan, S, Gros, A, Martinez-Quintanilla, J, Hemminki, A, Alemany, R

Journal:

Year:

2009

Language:

english

File:

PDF, 585 KB

english, 2009

33

Improved systemic antitumor therapy with oncolytic adenoviruses by replacing the fiber shaft HSG-binding domain with RGD

Rojas, J J, Gimenez-Alejandre, M, Gil-Hoyos, R, Cascallo, M, Alemany, R

Journal:

Year:

2012

Language:

english

File:

PDF, 373 KB

english, 2012

34

Combined Fiber Modifications Both to Target α v β 6 and Detarget the Coxsackievirus–Adenovirus Receptor Improve Virus Toxicity Profiles In Vivo but Fail to Improve Antitumoral Efficacy Relative to Adenovirus Serotype 5

Coughlan, Lynda, Vallath, Sabari, Gros, Alena, Giménez-Alejandre, Marta, Van Rooijen, N., Thomas, Gareth J., Baker, Andrew H., Cascalló, Manel, Alemany, Ramon, Hart, Ian R.

Journal:

Human Gene Therapy

Year:

2012

Language:

english

File:

PDF, 1.84 MB

english, 2012

35

Coagulation Factors Determine Tumor Transduction In Vivo

Gimenez-Alejandre, Marta, Cascallo, Manel, Bayo-Puxan, Neus, Alemany, Ramon

Journal:

Human Gene Therapy

Year:

2008

Language:

english

File:

PDF, 147 KB

english, 2008

36

Antitumor Therapy Based on Cellular Competition

Martinez-Quintanilla, Jordi, Cascallo, Manel, Fillat, Cristina, Alemany, Ramon

Journal:

Human Gene Therapy

Year:

2009

Language:

english

File:

PDF, 672 KB

english, 2009

37

Adeno-Associated Virus Enhances Wild-Type and Oncolytic Adenovirus Spread

Laborda, Eduardo, Puig-Saus, Cristina, Cascalló, Manel, Chillón, Miguel, Alemany, Ramon

Journal:

Human Gene Therapy Methods

Year:

2013

Language:

english

File:

PDF, 1.10 MB

english, 2013

38

Treatment of metastatic neuroblastoma with systemic oncolytic virotherapy delivered by autologous mesenchymal stem cells: an exploratory study

García-Castro, J, Alemany, R, Cascalló, M, Martínez-Quintanilla, J, del Mar Arriero, M, Lassaletta, Á, Madero, L, Ramírez, M

Journal:

Cancer Gene Therapy

Year:

2010

Language:

english

File:

PDF, 525 KB

english, 2010

39

Anti-migratory and anti-angiogenic effect of p16: A novel localization at membrane ruffles and lamellipodia in endothelial cells

Elena Alhaja, Jaume Adan, Roser Pagan, Francesc Mitjans, Manel Cascalló, Mercè Rodríguez, Veronique Noé, Carlos J. Ciudad, Adela Mazo, Senén Vilaró, Jaume Piulats

Journal:

Year:

2004

Language:

english

File:

PDF, 704 KB

english, 2004

40

Oncolytic viruses from the perspective of the immune system

Alemany, Ramon, Cascallo, Manel

Journal:

Future Microbiology

Year:

2009

Language:

english

File:

PDF, 390 KB

english, 2009

41

Deletion of VAI and VAII RNA Genes in the Design of Oncolytic Adenoviruses

Cascallo, Manel, Gros, Alena, Bayo, Neus, Serrano, Teresa, Capella, Gabriel, Alemany, Ramon

Journal:

Human Gene Therapy

Year:

2006

Language:

english

File:

PDF, 308 KB

english, 2006

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